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Dr. Prashant Joshi

Dr. Prashant Joshi

Assistant Professor
M. Pharm, Ph.D.

Areas of specialization: Drug design and Medicinal Chemistry of natural Products

Experience: Academic: 3 years, Research: 6 years

Interest areas:

 

  • Structure guided drug design of various natural and synthetic transmembrane efflux pumps, kinases and phosphatase enzymes inhibitors by virtual screening and MD simulation to decipher their intervention mechanism in bio-catalytic cascade of disease pathology.
  • Medicinal chemistry and SAR of natural compounds or nature inspired synthetic scaffolds.

 

Awards: Awarded CSIR-SRF 2012, Best Research Paper award 2015 at CSIR –IIIM jammu.

Patents: Total 19 {national (09) and international (10)} Selected patents granted in last 3 years are:

  1. Pharmaceutical composition for the treatment of multi-drug resistant infections. Vishwakarma, R. A., Kumar, A., Khan, I. A., Bharate. S. B., Joshi, P., Singh, S., Satti. N., A Indian Patent filed: 3077/DEL/2014. US 10, 064, 840 (Granted on Sept. 4, 2018 ) & European patent granted EP15807704.
  2. Rohitukine analogs as Cyclin dependent kinase inhibitors and a process for the preparation thereof; Vishwakarma, R. A.,Bharate, S. B.,Bhushan, S., Jain, S. K., Meena, S., Guru, S. K., Pathania, A. S., Kumar, S., Joshi, P., Bharate, S. S., Bahl, A., Mintoo, M. J. ; Indian Patent Filed: DE01142 European patent: EP2986605 (Granted on 15 Nov. 2017) CA2908084 US: US9932327B2.
  3. 10-Substituted colchicinoids as potent anticancer agents. Vishwakarma, R. A.,Bharate, S. B.,Kumar, A., Singh, B., Kumar, A., Bhushan, S., Hamid A., Joshi, P., Guru, S., Kumar, S., Hussain, A., Qazi, A. K., Bharate, S. S., Sharma, P., Saxena, A. K., Moondhe, D. M., Mahajan, G., Wani, Z. US Patent 9,868,695 (Granted on Jan. 16, 2018).
  4. Alkylidene Phosphonate esters as P-glycoprotein inducers. Bharate, S. B., Kumar, A., Manda, S., Joshi, P., Bharate, S. S., Wani, A., Sharma, S., Vishwakarma, R. A. WO 2016/063297 A1, Granted in EP - EP3209671 (Feb 2019).
  5. N-Substituted beta-carbolinium compounds as potent P-glycoprotein inducers. Bharate, S. B., Kumar, A., Manda, S., Joshi, P., Bharate, S. S., Vishwakarma, R. A.US Patent 10, 072,009 (Granted on Sep. 11, 2018).
  6. Polyalkylated acyl and benzoyl-phloroglucinols as potent P-glycoprotein inducers. Bharate, S. B., Kumar, A., Bharate, J. B., Joshi, P., Wani, A., Mudududdla R., Sharma R., Vishwakarma R. A., WO2016/063296 A1.Granted in US - US10202326B2 (Feb 2019).
  7. 6-Aryl-4-phenylaminoquinazolines as phosphoinositide 3 kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. Vishwakarma, R. A.,Bharate, S. B., Bhushan, S., Yadav, R. R., Guru, S. K., Joshi, P.EP3110801B1 (January 2019) And WO /2015/ 128873.
  8. Furanochalcone and Furanoflavones as inhibitors of CYP1A1, CYP1A2 and CYP1B1 for cancer chemoprevention Bharate, S. B., Sharma, R., Joshi, P., Vishwakarma, R. A., Chaudhuri, B. Indian Patent Application: (Prov. Date 12-08-2016) WO 2018029710 A4

Publications: Total 33 international publications. Selected publications in last 3 years are

 

  1. Joshi, P., Sonawane, V. R., McCann, G. J. P., Gatchie, L., Williams, I. S., Sharma, R. Satti, N. Chaudhuri, B., Bharate, S. B. Identification of karanjin isolated from Indian beech tree as potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural products repository. Med. Chem. Commun. (2018), 9, 371-382. (Impact Factor: 2.5)
  2. Joshi, P.*, Williams, I. S.*,  Gatchie, L., Sharma, M., Satti, N. K., Vishwakarma, R. A., Chaudhuri, B., Bharate, S. B., Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance. Bioorg. Med. Chem. Lett. (2017) 27, 3683-3687. * = Both author Contributed equally. (Impact factor: 2.42)
  3. Joshi, P., Vishwakarma, R. A. andBharate, S. B. Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer. Eur. J. Med. Chem. (2017) 138, 273-292. (Impact factor: 4.81)
  4. Joshi, P., McCann, J. G. P., Sonawane, V. R., Vishwakarma, R. A., Chaudhuri, B., Bharate, S. B. Identification of Potent and Selective CYP1A1 Inhibitors via Combined Ligand and Structure Based Virtual Screening and their In-vitro Validation in Sacchrosomes and Live human cells. J. Chem. Inf. Model. (2017), 57, 1309-1320.(Impact factor: 3.96)
  5. Joshi, P., Gupta, M., Kumar, A., Vishwakarma, R. A., Bharate S. B. (Z)-2-(3-Chlorobenzylidene)-3, 4-dihydro-N-(2-methoxyethyl)-3-oxo-2H-benzo[b][1,4] oxazine -6-carboxamide as GSK-3β inhibitor: Identification by virtual screening, and its validation in enzyme and cell-based assay. Chem. Biol. Drug. Des. (2017), 89, 964-971. (Impact factor: 2.4)
  6. Joshi, P., Singh, S., Wani, A., Sharma, S., Jain, S.K.,Singh, B., Gupta, B., Satti,N., Koul, S., Khan, I.A., Kumar, A., Bharate, S.B., Vishwakarma, R.A. Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: Reversing the resistance against frontline antibacterial drugs. Med. Chem. Commun. 2014, 5, 1540–1547. (Impact factor: 2.5)
  7. Horley, N. J., Beresford, K. J. M., Chawla, T., McCann, G.J.P., Ruparelia, K.C., Gatchie, L., Sonawane, V. R. Williams, I. S., Tan, H. L. Joshi, P., Bharate, S. B., Kumar, V. Bharate, S. B., Chaudhuri, B. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1 over-expressing cell lines. Eur. J. Med. Chem. (2017), 129, 159-174. (Impact Factor: 4.81)
  8. Singh, S., Kalia, N. P., Joshi, P., Kumar, A., Sharma, P. R., Kumar, A., Bharate, S. B., Khan, I. A. Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of Staphylococcus aureus and Human P-Glycoprotein, Reduces the Biofilm Formation and Intracellular Invasion of Bacteria. Front. Microbiol. (2017), 8, 1868-1873. (Impact Factor: 4.07)
  9. Horley,N. J., Beresford, K. J. M., Kaduskar, S., Joshi, P., McCann, G. J. P., Ruparelia,K. C., Williams, I. S., Gatchie, L., Sonawane, V. R., Bharate, S. B., Chaudhuri, B. (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent Bioorg. Med. Chem. Lett. (2017), 27 (24) 5409-5414. (Impact Factor: 2.42)
  10. Ibidapo S. Williams, Chib, S., Nuthakki, V. K., Gatchie, L., Joshi, P., Narkhede, N. A., Chaudhuri, B., Vishwakarma, R. A., Saran, S., Bharate, S. B. Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme. J. Agric. Food Chem. (2017), 65, 7440-7446. (Impact Factor: 3.15)
  11. Siddique, M. U. M., McCann, G. J. P., Sonawane, V., Horley, N., Gatchie, L. Joshi, P., Bharate, S. B., Jayaprakash, V., Sinha, B. N., Chaudhuri, B. Quinazoline derivatives as selective CYP1B1 inhibitors. Eur. J. Med. Chem. (2017), 130, 320-327. (Impact Factor: 4.81)

 

 

 

For complete list of publications and patents please visit:

https://www.researchgate.net/profile/Prashant_Joshi

https://scholar.google.co.in/citations?user=U5dErZIAAAAJ&hl=en

Official email ID: Prashant.joshi@nmims.edu

Official Phone No.: 02563245-51 Ext. 123

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