Dr. Amit Pandit

Areas of specialization:

Computer Aided Drug Design:

-Molecular Docking: GOLD suite, Surflex-Dock (SYBYL-X), Schrodinger suite programs, Discovery Studio, Molegro Virtual Docker

-Molecular Dynamics Simulations:Desmond (Schrodinger), Dynophore (MD analysis)

-2D/3D QSAR: CoMFA/CoMSIA (SYBYL-X), Schrodinger suite programs, MOE, Valstat

-3D Pharmacophore mapping:LigandScout, SYBYL-X, Discovery Studio

-Virtual Screening: LigandScout, ROCS (Openeye)

-Development of structure activity relationship (SAR) for small molecule inhibitors

Organic Chemistry

-Retrosynthetic analysis and synthetic scheme design

-Chemical Synthesis: Multi-step chemical synthesis, Solid-phase peptide synthesis, Heterocyclic synthesis, Microwave-assisted synthesis, Solvent-free synthesis, and Air/moisture sensitive synthesis

Chemical Characterization

-Purification and Characterizationof the pure compound using chromatographic techniques like TLC, HPLC, and Column Chromatography

-Spectral Interpretation: Well versed in the interpretation of IR, ¹H and ¹³C NMR, and LCMS

Experience:

- Industrial experience – 3.3 years

- Research experience – 8.6 years

- Academic experience – 3 months

Interest areas:

In-silico drug designing –Molecular docking/dynamics, QSAR, pharmacophore mapping, virtual screening

Organic synthesis and characterization of compounds – Solid phase and solution phase synthesis

Awards:

-Rising star postdoctoral research fellowship from Department of Biology, Chemistry, and Pharmacy, Freie University Berlin, 2021–2023.

-Project fellowship under DBT/BIRAC India sponsored Bio Ignition Grant at IIT Indore, 2020.

-Student exchange fellowship at Leibniz University Hannover, Germany, from German academic exchange service (DAAD), 2019.

-Ph.D. teaching assistantship from MHRD, India, 2015–2019.

-Young Scientist Award 2018 at International conference on innovation in pharmaceutical, medical, and biosciences (ICIPMBS-2018), Oriental university Indore.

-Royal Society of Chemistry Poster Presentation Award at the IIT Indore- RSC Symposium on Advances in Chemical Sciences, held at IIT Indore, 2018.

Patents:

• Third generation tubulysin analogues and process of preparation thereof, Venkatesh Chelvam, Amit Pandit,Ramesh B. Reddy, Kratika Yadav, Biswarup Pathak, Diptendu Roy, Grant Dec. 2022, Patent No.US11518786B2 US Patent.
• Small molecule inhibitors for early diagnosis of prostate specific membrane antigen cancers and neurodegenerative diseases, Venkatesh Chelvam, Sagnik Sengupta, Mena Asha Krishnan, Amit Pandit, PublishedMay 2020, Publication No. 2020/0164075A1, US Patent.
• Third generation tubulysin analogues and process of preparation thereof, Venkatesh Chelvam, Amit Pandit, Ramesh B. Reddy, Kratika Yadav, Biswarup Pathak, Diptendu Roy, Grant Jan 2024, Patent No. 498433, Indian Patent.
• New small molecule inhibitors/ligands for early diagnosis and therapy of prostate-specific membrane antigen (PSMA + ) cancers and neurodegenerative diseases, Venkatesh Chelvam, Sagnik Sengupta, Mena Asha Krishnan, Amit Pandit, Published May 2020, Application No. 201821044594, Indian Patent.

Number of Publications: 5

Recent Publications: (Last three years) (Please provide the details containing authors, title and other publication details):

• Structure-activity relationships (SAR) study to design and synthesize new tubulin inhibitors with enhanced anti-tubulin activity: in silico and in vitro analysis, Amit Pandit, Kratika Yadav, Ramesh B Reddy, Sagnik Sengupta, Rajesh Sharma, Venkatesh Chelvam, J. Mol. Struct. 2021, 1223, 129204–129216, DOI:- 10.1016/j.molstruc.2020.129204. IF- 3.84
• Imaging of prostate cancer: Optimizing affinity to prostate specific membrane antigen by spacer modifications in a tumor spheroid model, Mena Asha Krishnan, Amit Pandit, Rajesh Sharma, Venkatesh Chelvam, J. Biomol. Struct. Dyn. 2022, 40, 9909–9930, DOI:- 10.1080/07391102.2021.1936642. IF- 5.23

Other achievements/ Trainings:

Four days workshop on "Introduction to data analysis with R” by Freie University Berlin, Germany.

Online non-credit course on "Drug Discovery” authorized by University of California San Diego and offered through Coursera.

• Eight days GIAN workshop on "Advance concepts in the synthesis of pharmaceutical drugs” organized by Indian Institute of Technology Indore (IITI), India, in association with Illinois Wesleyan University, USA.
• 12 days GIAN workshop on "Chemical biology: The integration of chemistry, biology, and medicine” organized by Indian Institute of Technology Indore (IITI), India, in association with Purdue University, USA.
• 12 days GIAN workshop on "Chemistry and biology of carbohydrates” organized by Indian Institute of Technology Indore (IITI), India, in association with Max Planck Institute of colloids and interfaces, Germany.
• 8 days GIAN workshop on "Introduction of principles of green chemistry” organized by Indian Institute of Technology Indore (IITI), India, in association with Illinois Wesleyan University, USA.

Official email ID: amit.pandit@nmims.edu

Official Phone No.: 02563 - 295545/46/47/48/49