Dr. Swanand Sanjay Kulkarni

Assistant professor
M. Pharm., Ph.D.

Areas of specialization: Drug Discovery; CADD; Reproductive Endocrinology; Cancer.

Experience

Research experience: 4 years

Interest areas: Rational Drug Designing, Development and Biological Evaluation of Novel Chemical Entities for the Management of PCOS, Prostate Cancer and Breast Cancer

Awards:

1.Recipient of ICMR-SRF Fellowship

2.Recipient of DST-INSPIRE Fellowship

3.Recipient of Gold medal (M.Pharm., Central University of Punjab, Bathinda)

4.Recipient of Sitaram Jindal Foundation Sponsored Gold medal (M.Pharm., Central University of Punjab, Bathinda)

5.First prize in oral presentation at ISFCON-2023, held at ISF College of Pharmacy, Moga

Patents: 03 (Published)

Thareja S, Kumar S, Kulkarni S, Singh Y, Bhandary D, Prajapati SK. "Novel Polyphenolic Boron Adducts, their Synthesis and Uses thereof” (Indian Patent Application No. 202311006635)
Thareja S, Jain AK, Banjare L, Verma SK, Rai S, Vishvakarma NK, Kumar S, Kulkarni S, Singh Y. "Novel (1E,6E)-1-(4-(2-([1,1'-biphenyl]-4-yl)-2-oxoethoxy)-3-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, its synthesis and uses thereof” (Indian Patent Application No. 202311001450)
Jain AK, Kumar S, Thareja S, Rai S, Singh K, Biharee A, Kulkarni S. "Novel Docetaxel Polymersomes, Formulation and Uses” (Indian Patent Application No. 202321042473)

Books/Book chapters published:

Singh, Y., Kulkarni, S., & Thareja, S. (2023). Thioether linkage chemistry: perspectives and prospects in therapeutic designing. Polymer-Drug Conjugates, 193-206.Number of Publications: 14

Recent Publications: (Last three years) (Please provide the details containing authors, title and other publication details):

Kulkarni, S., Gupta, K., Ratre, P., Mishra, P. K., Singh, Y., Biharee, A., & Thareja, S. (2023). Polycystic ovarian syndrome: Current scenario and future insights. Drug Discovery Today, 103821.
Kulkarni, S., Singh, Y., Biharee, A., Bhatia, N., Monga, V., & Thareja, S. (2023). Molecular docking, 3D-QSAR and simulation studies for identifying pharmacophoric features of indole derivatives as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) inhibitors. Journal of Biomolecular Structure and Dynamics, 41(22), 12668-12685.
Kulkarni, S., Bhandary, D., Singh, Y., Monga, V., & Thareja, S. (2023). Boron in cancer therapeutics: An overview. Pharmacology & Therapeutics, 108548.
Das, S., Kulkarni, S., Singh, Y., Kumar, P., & Thareja, S. (2022). Selective Estrogen Receptor Modulators (SERMs) for the treatment of ER+ breast cancer: An overview. Journal of Molecular Structure, 1270, 133853.
Ratre, P., Kulkarni, S., Das, S., Liang, C., Mishra, P. K., & Thareja, S. (2022). Medicinal chemistry aspects and synthetic strategies of coumarin as aromatase inhibitors: an overview. Medical Oncology, 40(1), 41.
Singh Y, Sanjay KS, Kumar P, Singh S, Thareja S. Molecular dynamics and 3D-QSAR studies on indazole derivatives as HIF-1α inhibitors. Journal of Biomolecular Structure and Dynamics. 2023 May 24;41(8):3524-41.
Biharee, A., Singh, Y., Kulkarni, S., Jangid, K., Kumar, V., Jain, A. K., & Thareja, S. (2024). An amalgamated molecular dynamic and Gaussian based 3D-QSAR study for the design of 2, 4-thiazolidinediones as potential PTP1B inhibitors. Journal of Molecular Graphics and Modelling, 127, 108695.
Bhatia, N., Khator, R., Kulkarni, S., Singh, Y., Kumar, P., & Thareja, S. (2023). Recent advancements in the discovery of MDM2/MDM2-p53 Interaction inhibitors for the treatment of cancer. Current Medicinal Chemistry, 30(32), 3668-3701.
Singh, Y., Kumar, N., Kulkarni, S., Singh, S., & Thareja, S. (2023). Pharmacophore derived 3D-QSAR, molecular docking, and simulation studies of quinoxaline derivatives as ALR2 inhibitors. Journal of Biomolecular Structure and Dynamics, 1-37.
Khator, R., Biharee, A., Bhatia, N., Kulkarni, S., Singh, Y., Karthikeyan, C., Jain, A. K., & Thareja, S. (2024). Medicinal Aspects of PTP1B Inhibitors as Anti-Breast Cancer Agents: An Overview. Current Medicinal Chemistry, 31(34), 5535-5549.
Tantra, T., Singh, Y., Patekar, R., Kulkarni, S., Kumar, P., & Thareja, S. (2024). Phosphate prodrugs: an approach to improve the bioavailability of clinically approved drugs. Current Medicinal Chemistry, 31(3), 336-357.
Singh, Y., Bhatia, N., Biharee, A., Kulkarni, S., Thareja, S., & Monga, V. (2023). Developing our knowledge of the quinolone scaffold and its value to anticancer drug design. Expert Opinion on Drug Discovery, 18(10), 1151-1167.
Biharee, A., Yadav, A., Jangid, K., Singh, Y., Kulkarni, S., Sawant, D. M., Kumar, P., Thareja, S, & Jain, A. K. (2023). Flavonoids as promising anticancer agents: an in silico investigation of ADMET, binding affinity by molecular docking and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics, 41(16), 7835-7846.

Professional memberships:

Lifetime member of Indian Society for the Study of Reproduction and Fertility (ISSRF) – (Membership No.: 1796)
Student member – Royal Society of Chemistry (Membership ID: 746427)

Other achievements/ Trainings:

Qualified GPAT-2020.
Attended International webinar series on "Recent Advances & Innovations in Reproductive Health” organized by the Department of Zoology, IIT-BHU, and Indian Society for the Study of Reproduction and Fertility (ISSRF) on September 20 and 21, 2024.
Attended workshop on "Good animal handling practices” on World Animal Day at Poona College of Pharmacy, Pune, held on October 4, 2024.
Participated in one-day National seminar on "Importance of Pharmacovigilance in Healthcare System” organized by ISF College of Pharmacy, Moga, held on 10th May, 2023
Participated in National Workshop on "IP: Accelerating Innovation and Creativity” organized by ISF College of Pharmacy, Moga, held on 26th April, 2023
Participated in "Hands on Workshop on SciFinder” organized by the Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, held on 12th April, 2023
Participated in the one-day workshop "Basics of Systematic Review and MetaAnalysis”, held at the Central University of Punjab, on 21st March, 2023
Participated in a CME on "Scientific Publication” organized by the Department of Pharmacology and Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, under the aegis of Indian Pharmacological Society (IPS), held on 13th March, 2023
First prize for oral presentation at the ISFCON-2023, held at ISF College of Pharmacy, Moga, on 11th and 12th February, 2023
Participated, attended and presented poster at the the 72nd Indian Pharmaceutical Congress, held at Nagpur, Maharashtra, from 20th January to 22nd January, 2023 (Travel was assisted by the CUPB Travel Grants’ Scheme).
Participated in the Online Workshop on "Intellectual Property Rights (IPRs) and IP management for Startup” held on 16th August, 2022 organized by Central University of Punjab.
Workshop on Intellectual Property Rights (IPRs) and Entrepreneurship organized by Central University of Punjab. (27th April 2022)
Hit Identification and Lead Optimization using SeeSAR and StarDrop” organized in Collaboration with Zastra Innovations organized by Central University of Punjab (29th January, 2022)
"Cloud-based Hands-on Workshop: Computational Structure-based Drug Design” organized by ISF College of Pharmacy (ISFCP), Moga in collaboration with Schrödinger Inc. (24th January, 2022)
Attended workshop on "Advanced Session on Patenting Strategies and Patent Search Exercise for Inventions in Pharmaceutical Sciences” held on 1st December, 2021.