Dr. Ranajit N. Shinde

Associate Professor
M.S., Ph. D.

Areas of Specialization

Computer aided drug design, Molecular dynamics, QSAR,

Professional Experience

Industrial: 2 Years
Academic: 8 Years
Postdoctoral Research: 2 Years

Research Interest

Molecular dynamics, Molecular docking, ADMET model development using Artificial Intelligence, Computer aided drug design, In vitro assay, protein-ligand co-crystallisation

Awards

Awarded and completed EMBO-Short Term Fellowship to perform collaborative research with Dr. Stefan Knapp at Pharmaceutical Chemistry department of Goethe University, Frankfurt, Germany
Awarded the CSIR-Nehru Science Postdoctoral Research Fellowship by Council of Scientific and Industrial Research (CSIR), Government of India, New Delhi, for three years.
Awarded the Senior Research Fellowship (SRF) by the Council of Scientific and Industrial Research (CSIR), Government of India, New Delhi, for four years.
Selected as a young researcher to deliver a talk at "Annual Symposium of the Indian Biophysical Society, 2017.
Received Galderma Travel award of 1000 SGD for the oral presentation at international conference "Pharmacy Medicinal Chemistry Symposium, 2010, Singapore”

Total Number of Publications: 20

Recent Publications:

Saurabh B. Ganorkar, Preeti S. Bobade, Rakesh C. Prabhu, Deepak K. Lokwani, Ranajit N. Shinde, Darshan R. Telange, Atul A. Shirkhedkar, Yvan Vander Heyden, Extension of impurity profiling on eltrombopag olamine to in-silico predictions: An effort to exploit correlated forced degradation products and known drug-related substances in drug discovery. Journal of Chromatography B, 2024, 1248, 124367.
Structurally disordered C-terminal residues of GTP cyclohydrolase II are essential for its enzymatic activity. S Yadav, RN Shinde, S Singh, S Karthikeyan, B Singh. Journal of Biomolecular Structure and Dynamics. 2022, 40 (19), 9318.
Screening and identification of potential PTP1B allosteric inhibitors using in silico and in vitro approaches. RN Shinde, GS Kumar, S Eqbal, ME Sobhia. PloS one. 2017. 13 (6), e0199020
Shinde RN, Subramanian K, Singh B. Molecular dynamics studies unravel role of conserved residues responsible for movement of ions into active site of DHBPS, 2017. Scientific Reports 7, 40452.(IF – 5.228)
Shinde RN, Sobhia ME. Binding and discerning interactions of PTP1B allosteric inhibitors: Novel insights from molecular dynamics simulations. J Mol Graph Mod,2013, 45, 98–110.(IF – 2.022)
Shinde RN, Sobhia ME. Geometrical criteria for characterizing open and closed states of WPD-loop in PTP1B. J Mol Struct, 2012, 1017, 79–83.(IF – 1.404)
Sobhia ME, Paul S, Shinde RN, Potluri M, Gundam V, Kaur A, Haokip T. Protein tyrosine phosphatase inhibitors: a patent review (2002 - 2011). Expert Opin Ther Pat, 2012, 22(2), 125-153. (IF – 3.525)
Shah A, Shinde R, Kare P, Hymavathi, Chavan S and Sobhia ME. Induced fit binding of aldose reductase inhibitors to AKR1B10. Med Chem Res, 2012 21(7), 1245-1252.(IF – 1.612)
Shinde RN, Srikanth K, Sobhia ME. Insights into the permeability of drugs and drug‐like molecules from MI‐QSAR and HQSAR studies. J Mol Model, 2012, 18(3), 947-962.(IF – 1.984)
Kumar R, Shinde RN, Ajay D, Sobhia ME. Probing interaction requirements in PTP1B inhibitors: A comparative molecular dynamics study. J Chem Inf Mod, 2010, 50(6), 1147‐1158.(IF – 3.822)
Shinde RN, Gupta S and Mohan CG. Information rich descriptors for predicting p-glycoprotein substrates and nonsubstrates: A binary-QSAR approach. Chem Biol Interface, 2012, 2(3), 140-156.
Shinde R, Garg D, Wahajuddin, Mohan CG. Impact of structural bioinformatics on drug discovery, Cur Res Inf Pharm Sci, 2005, July, 17-23.