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Mukesh Patel School of Technology Management and Engineering
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  • Assistant Professor
  • SPTM
  • M.Pharm, Ph.D (Thesis Submitted)

Areas Of Specialization Pharmaceutical and Organic Chemistry
Experience: 4 years

Interest areas: Molecular modeling-guided design, synthesis and evaluation of novel small molecule inhibitors for cancer therapy.

 

Awards & Fellowship:

 

  1. DST–INSPIRE Fellowship: Awarded for doctoral research in Pharmaceutical/Medicinal Chemistry.
  2. ICMR- Junior Research Fellowship (JRF)
  3. Recipient of Gold medal (M.Pharm., Guru Ghasidas Vishwavidyalaya-A Central University, Bilaspur, Chhattisgarh)
  4. Recipient of Gold medal (B. Pharm., Guru Ghasidas Vishwavidyalaya-A Central University, Bilaspur, Chhattisgarh)

Patents: 02

  1. A system to synthesize sulfamoyl based hydroxamates and evaluate anticancer activity of the hydroxamates thereof. Application no. DE202023105438U1, dated 2023.11.09, German Patent.
  2. A process for synthesizing N-(6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-8- yl)benzenesulfonamide derivatives for anticancer activities Application no. 2021/10563, dated 2022.07.29, South African Patent.

 

Books/Book chapters: 07

 

  1. Vishwakarma SK, Singh V, Shirbhate E, Kore RK, Patel VK, Rajak H. Regulatory and ethical considerations in plant-based nanomedicine. In: Chaurasia PK, Bharati SL, Singh S, Mani A, editor. Plant-associated medicinal nano-chemistry. CRC Press;2026. p. 191-203.
  2. Singh V, Shirbhate E, Rajak H. AI in precision oncology and personalized cancer treatments. In: Pradhan J, Shukla AK, editor. AI-Personalized Medicine Therapy. Cambridge Scholars Publishing;2025. p. 458-483.
  3. Singh V, Shirbhate E, Rajak H. AI in pharmacogenomics and personalized cancer treatments. In: Pradhan J, Shukla AK, editor. AI-Personalized Medicine Therapy. Cambridge Scholars Publishing;2025. p. 484-507.
  4. Singh V, Shirbhate E, Kore R, Rajak H. Integration of multi-omics data using AI for personalized In: Pradhan J, Shukla AK, editor. AI-Personalized Medicine Therapy. Cambridge Scholars Publishing;2025. p. 508-527.
  5. Patel VK, Rajak H, Shirbhate E, Kumar A, Singh SK. Combretum caffrum confers a potential cutting-edge anticancer molecule as In: Chaurasia PK, Bharati SL, Singh S, editor. The Chemistry inside Spices and Herbs: Research and Development. Bentham Science;2024. p. 01-16.
  6. Kore R, Tiwari P, Patel VK, Shirbhate E, Veerasamy R, Mishra A, Rajak Memantine and glutamate antagonists in the treatment of Alzheimer’s disease: Current updates. In: Kumar D, Tiwari P, editor. Enzymatic Targets for Drug Discovery against Alzheimer’s disease. Bentham Science;2023. p. 111-120.
  7. Patel VK, Shirbhate E, Rajak H. Coronavirus reinfections: An outlook on evidences and effects. In: Kaklauskas A, Abraham A, Okoye K, Guggari S. Lessons from COVID-19 impact on Healthcare Systems and Technology. Academic Press;2022. p. 19-40.

Total Number of Publications: 25
Recent Publications: (Last three years): 16

  1. Shirbhate E, Singh V, Prabha V, Karthikeyan C, Tiwari AK, Veersamay R, Yasin HKA, Rajak Patent landscape in hydroxamic acid-based HDAC inhibitors (2020-2024): structure- activity relationships and mechanistic insights. Expert Opinion on Therapeutic Patents 2025;1-http://doi.org/10.1080/13543776.2025.2591483 (Impact Factor: 4.6)
  2. Singh V, Parveen S, Patel VK, Shirbhate E, Veerasamy R, Tiwari AK, Rajak H. HDAC inhibitors in haematological and solid tumor therapy: Current success, challenges, and future Current Topics in Medicinal Chemistry 2025. http://doi.org/10.2174/0115680266385393251115155753 (Impact Factor: 3.3)
  3. Singh V, Shirbhate E, Kore R, Veerasamy R, Sharma PC, Tiwari AK, Rajak H. Targeting microbiome-derived exosomes to overcome cancer therapy resistance: Mechanisms, implications, and opportunities. Mini Review in Medicinal Chemistry 2025. http://doi.org/2174/0113895575416455251014053321 (Impact Factor: 3.862)
  4. Shirbhate E, Koch B, Singh V, D, Koch B, Dubey A, Yasin HKA, Rajak H. Heteroaryl- capped hydroxamic acid derivatives with varied linkers: Synthesis and anticancer evaluation with various apoptosis analyses in breast cancer cells, including docking, simulation, DFT, and ADMET Studies. Pharmaceuticals 2025;18,1148. https://doi.org/10.3390/ph18081148 (Impact Factor: 4.8)
  5. Shirbhate E, Singh V, Kore R, Koch B, Veerasamy R, Tiwari AK, Rajak H. Synergistic strategies: Histone deacetylase inhibitors and platinum-based drugs in cancer Expert Review of Anticancer Therapy 2025;1-21. https://doi.org/10.1080/14737140.2025.2458156 (Impact Factor: 2.8)
  6. Patel VK, Shirbhate E, Singh V, Parveen S, Veerasamy R, Tiwari AK, Rajak Strategies to combat resistance to anti-angiogenesis therapies in cancer: Current status and future prospects. Current Topics in Medicinal Chemistry 2025. https://doi.org/10.2174/0115680266324868250123052818 (Impact Factor: 3.862)
  7. Singh V, Shirbhate E, Kore R, Vishwakarma SK, Parveen S, Veerasamy R, Tiwari AK, Rajak Microbial metabolites-induced epigenetic modifications of colorectal cancer: Current status and Future perspectives. Mini-Reviews in Medicinal Chemistry 2024;25(1):76-93. https://doi.org/10.2174/0113895575320344240625080555 (Impact Factor: 3.862)
  8. Kumar Kore R, Shirbhate E, Singh V, Mishra A, Veerasamy R, Rajak New investigational drug’s targeting molecular pathways for treatment of cervical cancer: Current status and Future prospects. Cancer    Investigation 2024;42(7):627-642. https://doi.org/10.1080/07357907.2024.2373841 (Impact Factor: 1.9)
  9. Singh V, Shirbhate E, Kore R, Mishra A, Jahoriya V, Veerasamy R, Tiwari AK, Rajak H. Dietary plant metabolites induced epigenetic modification as a novel strategy for the management of prostate cancer. Mini-Reviews in Medicinal Chemistry 2024;24(15):1409- 1426. https://doi.org/10.2174/0113895575283895240207065454 (Impact Factor: 3.862)
  10. Shirbhate E, Singh V, Mishra A, Jahoriya V, Veerasamy R, Tiwari AK, Rajak Targeting lysosomes: A strategy against chemoresistance in cancer. Mini-Reviews in Medicinal Chemistry 2024;24(15):1449-1468.   https://doi.org/10.2174/0113895575287242240129120002 (Impact Factor: 3.862)
  11. Patel VK, Vaishnaw A, Shirbhate E, Kore R, Singh V, Veerasamy R, Rajak Cortisol as a target for treating mental disorders: A promising avenue for therapy. Mini-Reviews in Medicinal Chemistry      2024;24(6):588-600. https://doi.org/10.2174/0113895575262104230928042150 (Impact Factor: 3.862)
  12. Shirbhate E, Singh V, Kore R, Vishwakarma S, Veerasamy R, Tiwari AK, Rajak H. The role of cytokines in activation of tumour-promoting pathways and emergence of cancer drug resistance. Current Topics in Medicinal Chemistry 2024;24(6):523-540. https://doi.org/10.2174/0115680266284527240118041129 (Impact Factor: 3.862)
  13. Shirbhate E, Singh V, Jahoriya V, Mishra A, Veerasamy R, Tiwari AK, Rajak H. Dual inhibitors of HDAC and other epigenetic regulators: A novel strategy for cancer treatment. European Journal   of   Medicinal       Chemistry 2024;263(6):115938. https://doi.org/10.1016/j.ejmech.2023.115938 (Impact Factor: 5.9)
  14. Patel P, Shrivastava SK, Sharma P, Kurmi BD, Shirbhate E, Rajak H. Hydroxamic acid derivatives as selective HDAC3 inhibitors: computer-aided drug design strategies. Journal of Biomolecular Structure and Dynamics 2023;42(1):362-383. https://doi.org/10.1080/07391102.2023.2192804 (Impact Factor: 2.4)
  15. Shirbhate E, Pandey J, Patel VK, Veerasamy R, Rajak Exploration of structure-activity relationship using the integrated structure and ligand based approach: Hydroxamic acid-based HDAC inhibitors and cytotoxic agents. Turkish Journal of Pharmaceutical Sciences 2023;20(4):270-284. https://doi.org/10.4274/tjps.galenos.2022.12269 (Impact Factor: 2.0)
  16. Patel VK, Shirbhate E, Tiwari P, Kore R, Veerasamy R, Mishra A, Rajak Multi-targeted HDAC inhibitors as anticancer agents: Current status and Future prospective. Current Medicinal Chemistry      2023;30(24):2762-2795. https://doi.org/10.2174/0929867329666220922105615 (Impact Factor: 4.1)

 

Other achievements/ Trainings:

  1. GPAT qualifier (2019)
  2. Oral presentation award at National Seminar on “Herbal Medicines: Opportunities for Pharmacists to incorporate Traditional medicine into Modern Healthcare” on Oct 06-07, 2023 organized by Raigarh College of Pharmacy, Raigarh (C.G.).
  3. Best poster presentation award at International Seminar on “Importance and Awareness of Traditional and Alternative medicines” on Aug 25-26, 2023 jointly organized by Skyline University, Nigeria, Africa and Shri Shankaracharya Professional University (SSPU), Bhilai, (C.G.).

Official email ID: ekta.shirbhate@nmims.edu

Official Phone No. 02563-295545,131142 (ext.)